Preheat the Panini Press or Grill Pan: If you have a panini press, preheat it according to the manufacturer's instructions. If you don't have a press, you can use a grill pan or a regular skillet..
Assemble the Panini: Start with one slice of bread as the base.
Spread a layer of cranberry sauce on the bread. This will add a sweet and tangy element to your panini.
Add the leftover turkey slices on top of the cranberry sauce.
Place the leftover stuffing on top of the turkey. Spread it out evenly.
Add a slice or two of your favorite cheese on top of the stuffing. The cheese will help hold the panini together and add a creamy element.
Finish with the second slice of bread as the top.
Spread a thin layer of butter on the outside of the bread slices. This will give your panini a golden and crispy crust.
Place the panini in the preheated press or grill pan. If you're using a skillet, you can cook it like a grilled cheese sandwich.
Grill the panini for 3-5 minutes, or until the bread is golden brown and the cheese is melted. You can press down gently with a spatula if using a skillet.
Remove the Thanksgiving Leftover Panini from the grill.
Let it cool for a minute to avoid burning your mouth, then slice it in half.
Serve your panini with your favorite side, such as a small bowl of leftover gravy for dipping, and enjoy!